Single-neuron sequencing shows that widespread genomic abnormalities are common prenatally but largely eliminated around birth, indicating developmental genome quality control in human neurons.

Sensorimotor and amygdala activation, but not canonical prefrontal control circuits, indicate emotion regulation capacity.

Phase 1 of TenK10K takes single-cell RNA sequencing and matched whole-genome sequencing data from 1,925 individuals, enabling detection of associations for common and rare genetic variants, the latter of which have been uncharacterized in their impa…

In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac energetics and preventing stress-i…

In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing neoantigen-driven autoimmune immunit…

Flowers apparently weren't enough to ask for an ancestor's blessing.

California has broken a decades-old record for rabid animals this year, but public health officials aren't sure what's causing the increase.

Industry scientists were aware of the potential risks of microplastics as early as the 1970s, an investigation reveals.

One in three individuals with major depressive disorder does not get relief from standard daily antidepressant medications. The up-and-coming psychedelic therapeutics like psilocybin or LSD do show promise of quick relief, even for difficult-to-treat depressi…